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Products Details
Product Description
– CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.
CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
Web ID
– HY-125836
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H28Cl2N6O
References
– [1]Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.
CAS Number
– 2206788-99-8
Molecular Weight
– 511.45
SMILES
– ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology
Solubility
– 10 mM in DMSO
Target
– CCR
Isoform
– CCR4
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
