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Products Details
Product Description
– CCR4 antagonist 2 (Compound 31) is a novel, potent, orally bioavailable small molecule antagonist of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+ flux and [chemotaxis] CTX at 40 nM and 70 nM, respectively.
Web ID
– T10713
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H28Cl2N6O
References
– Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.
CAS Number
– 2206788-99-8
Molecular Weight
– C26H28Cl2N6O
SMILES
– [C@H](C)(N1C=2C(C(C#N)=N1)=NC=C(N2)C=3C[C@@H](C)[C@H](CC3)N4[C@H](CO)CCC4)C5=C(Cl)C=C(Cl)C=C5
Target
– Others
Pathway
– Membrane transporter/Ion channel|||Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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