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Products Details
Product Description
– Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells[1].
Web ID
– HY-152204
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H33BrN4O4S
References
– [1]Huang H, et al. Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells. Bioorg Med Chem Lett. 2022 Nov 23;80:129087.
Molecular Weight
– 613.57
SMILES
– O[C@@H](COC[C@H](NS(=O)(C1=CC=C(C=C1)Br)=O)CC2=CC=CC=C2)CN(CC3)CCN3C(C=CC=C4)=C4C#N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin L;Cathepsin S
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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