Carfilzomib
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Carfilzomib

SKU T1795-5 mg Category Brand:

Price range: 77 CAD through 302 CAD

Products Details

Product Description

– Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.

Web ID

– T1795

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C40H57N5O7

Citations

– 1. Zhou Q, Liang J, Yang T, et al. Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer. EMBO Molecular Medicine. 2022 Jan 11;14(1):e14502. doi: 10.15252/emmm.202114502. Epub 2021 Dec 13. 2. Kunder R, Velyunskiy M, Dunne S F, et al. Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer. Cell Chemical Biology. 2021 3. Qu X, Liu H, Song X, et al. Effective degradation of EGFRL858R+ T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. European Journal of Medicinal Chemistry. 2021, 218: 113328.

References

– Kuhn DJ, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90.

CAS Number

– 868540-17-4

Molecular Weight

– C40H57N5O7

Compound Purity

– 0.9984

SMILES

– CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

Target

– Dopamine Receptor

Pathway

– Autophagy|||Proteases/Proteasome|||Ubiquitination|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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