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Products Details
Product Description
– Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].
Web ID
– HY-150570
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H17N7O2S
References
– [1]Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.
CAS Number
– 2410402-75-2
Molecular Weight
– 395.44
SMILES
– O=S(C1=CC=C(/N=N/C2=C(NC(C3=CC=C(C)C=C3)=C4)N4N=C2N)C=C1)(N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase;CDK
Isoform
– CA â…¡;CA â…¨;CA I;CA XII;CDK2
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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