Download Files:
Products Details
Product Description
– Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines[1].
Web ID
– HY-115999
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H22BrN5O5S2
References
– [1]Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.
CAS Number
– 2883451-38-3
Molecular Weight
– 640.53
SMILES
– COC1=CC=C(C(C2=NC(SCC(C3=CC=C(C=C3)Br)=O)=NC(NC4=CC=C(C=C4)S(N)(=O)=O)=C2C#N)=C1)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¡
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
