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Calyculin A
SKU
HY-18983-10 μg (0.5 mM * 20 μL in DMSO)
Category Reference compound
Tags Cancer, Metabolic Enzyme/Protease, Phosphatase
$120 – $580
Products Details
Product Description
– Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].
Web ID
– HY-18983
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C50H81N4O15P
References
– [1]Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.|[2]Hiroaki Tanaka,et al. Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. Int J Oncol. 2007 Aug;31(2):389-96.
CAS Number
– 101932-71-2
Molecular Weight
– 1009.17
Compound Purity
– 99.67
SMILES
– O[C@@H]([C@H]([C@@H](N(C)C)COC)O)C(NCC[C@@H](C1=NC(/C=C/C[C@@H]([C@@H](C)[C@H](O)C2)O[C@@]32C(C)(C)[C@@H](OP(O)(O)=O)[C@@H]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=CC#N)O3)=CO1)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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