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CA77.1
$66 – $550
Products Details
Product Description
– CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer’s disease research[1].
Web ID
– HY-134923
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H12ClN3O
References
– [1]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184(10):2696-2714.e25.
CAS Number
– 2412270-22-3
Molecular Weight
– 297.74
Compound Purity
– 98.98
SMILES
– CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
