– MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene. MRTO4, also known as MRT4, belongs to the universal ribosomal protein uL10 family. This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. MRTO4 is a nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. The precise function of MRTO4 is currently unknown. It appears to be involved in mRNA turnover and ribosome assembly. MRTO4 is widely expressed in the appendix, lymph node, and other tissues. Diseases associated with MRTO4 include Bacterial Conjunctivitis and Robinow Syndrome, Autosomal Dominant 1.