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BX471
$103 – $539
Products Details
Product Description
– BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
Web ID
– HY-12080
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H24ClFN4O3
Citations
– Cell Res. 2018 Mar;28(3):323-335. |Immunol Lett. 2018 Oct 12;204:29-37. |J Inflamm Res. 2020 Jul 21;13:343-356.|Lab Invest. 2020 Apr;100(4):619-629.|Research Square Preprint. 2021 Oct.|Sci Adv. 2021 May 26;7(22):eabb5943.|Sci Rep. 2020 Nov 25;10(1):20508.|Cancer Cell. 2021 Mar 8;39(3):423-437.e7.|J Exp Clin Cancer Res. 2022 Mar 3;41(1):81.|Signal Transduct Target Ther. 2021 Feb 28;6(1):91.
References
– [1]Liang M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.|[2]Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.|[3]Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.|[4]Horuk R, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem. 2001 Feb 9;276(6):4199-204.
CAS Number
– 217645-70-0
Molecular Weight
– 434.89
Compound Purity
– 99.94
SMILES
– O=C(N)NC1=CC(Cl)=CC=C1OCC(N2[C@H](C)CN(CC3=CC=C(F)C=C3)CC2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Target
– CCR
Isoform
– CCR1
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
