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Bufalin
Price range: 88 CAD through 315 CAD
Products Details
Product Description
– Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
Web ID
– T1719
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H34O4
Citations
– 1. Chen F, Zhu L, Hu J, et al. Bufalin attenuates triple‑negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4. Oncology letters. 2020, 20(5): 1-1.
2. Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway
References
– Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.
CAS Number
– 465-21-4
Molecular Weight
– C24H34O4
Compound Purity
– 0.9908
SMILES
– [H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2
Target
– Tyrosinase|||NF-κB
Pathway
– Membrane transporter/Ion channel
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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