Download Files:
Bryostatin 3
$641
Only 1000 item(s) left in stock.
Products Details
Product Description
– Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].
Web ID
– HY-108602
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C46H64O17
References
– [1]Wender PA, et, al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7197-201.|[2]Mackanos EA, et, al. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J Biol Chem. 1991 Jun 15;266(17):11205-12.
CAS Number
– 143370-84-7
Molecular Weight
– 888.99
SMILES
– CCC/C=C/C=C/C(O[C@H]1C([C@@](O2)([H])[C@]3([H])O[C@]1(C(C)(/C=C[C@](C/4)([H])O[C@](CC4=CC(OC)=O)([H])C[C@@](C(C)([C@@H](OC(C)=O)C[C@@]5([H])C[C@@H](O)CC(OC([C@H](O)C)C3)=O)C)(O5)O)C)O)=CC2=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PKC
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
