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Brusatol
Price range: 53 CAD through 1,579 CAD
Products Details
Product Description
– Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
Web ID
– TQ0211
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H32O11
Citations
– 1. Wang Y, Ma H, Huang J, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. European Journal of Medicinal Chemistry,. 2021 Feb 15;212:113030
2. Li J, Hao M, Liu M, et al. Transcutaneous Electrical Acupoint Stimulation Pretreatment Alleviates Cerebral Ischemia–Reperfusion Injury in Rats by Modulating Microglia Polarization and Neuroinflammation Through Nrf2/HO-1 Signaling Pathway. Neurochemical Research. 2022: 1-12.
3. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567.
4. Wang M, Hu S, Yang J, et al.Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis.Phytomedicine.2024: 155391.
References
– Olayanju A, et al. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammaliancells to chemical toxicity-implications for therapeutic targeting of Nrf2. Free Radic Biol Med. 2015 Jan;78:202-12.
CAS Number
– 14907-98-3
Molecular Weight
– C26H32O11
Compound Purity
– 0.9995
SMILES
– COC(=O)[C@]12OC[C@@]34[C@H]1[C@@H](OC(=O)C=C(C)C)C(=O)O[C@@H]3C[C@H]1C(C)=C(O)C(=O)C[C@]1(C)[C@H]4[C@@H](O)[C@@H]2O
Pathway
– Immunology/Inflammation|||Apoptosis
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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