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BRM/BRG1 ATP Inhibitor-1
Price range: 667 CAD through 3,888 CAD
Products Details
Product Description
– BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
Web ID
– T10616
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C11H9F3N4O2S
Citations
– 1. Yao X, Hong J H, Nargund A M, et al.PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.Nature Cell Biology.2023: 1-13.
References
– Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
CAS Number
– 2270879-17-7
Molecular Weight
– C11H9F3N4O2S
Compound Purity
– 0.9984
SMILES
– OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Target
– Cannabinoid Receptor
Pathway
– Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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