Brepocitinib P-Tosylate
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Brepocitinib P-Tosylate

SKU T12427-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,059 CAD

Products Details

Product Description

– Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).

Web ID

– T12427

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H29F2N7O4S

References

– Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.

CAS Number

– 2140301-96-6

Molecular Weight

– C25H29F2N7O4S

Compound Purity

– 0.9997

SMILES

– Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1

Pathway

– Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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