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BpV(HOpic)
$270
Only 1000 item(s) left in stock.
Products Details
Product Description
– BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2].
Web ID
– HY-128693
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C6H4K2NO8V
References
– [1]Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566(1-3): 35-8.|[2]Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17(1): 414-421.|[3]Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34(2): 125-36.|[4]Raffel N, et, al. The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54(8): 1057-1063.|[5]Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17(4): 474-82.|[6]Zhou J,et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7(1): 9503.|[7]Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8(29): 18741-53.
CAS Number
– 722494-26-0
Molecular Weight
– 347.24
Compound Purity
– 98.0
SMILES
– O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC(O)=CC=C4C3=O.[2 K+]
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 2.89 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– PTEN
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
