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Products Details
Product Description
– BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects[1].
Web ID
– HY-114785
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H20N2O4S
References
– [1]R Maekawa, et al. Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor. Cancer Res. 1999 Mar 15;59(6):1231-5.
CAS Number
– 193807-60-2
Molecular Weight
– 396.46
SMILES
– O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N[C@H](CC3=CC=CC=C3)C(NO)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-1;MMP-14;MMP-2;MMP-3;MMP-7;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
