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Products Details
Product Description
– BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC50 value of 0.4 nM. BMS-98614 has excellent antithrombotic effect[1][2].
Web ID
– HY-150790
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C27H23N5O5S2
References
– [1]E Scott Priestley, et al. Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem. 2022 Jul 14;65(13):8843-8854.|[2]P Wong, et al. Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys. European Heart Journal, Volume 41, Issue Supplement_2, November 2020.
CAS Number
– 1478711-48-6
Molecular Weight
– 561.63
SMILES
– O=C(N(C)C)C1=CC=C(C2=NC(COC3=C4C=C(C5=CN6C(SC(OC)=N6)=N5)OC4=CC(OC)=C3)=CS2)C=C1
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Protease Activated Receptor (PAR)
Isoform
– PAR4
Pathway
– GPCR/G Protein
Product type
– Reference compound
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