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Products Details
Product Description
– BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities[1].
Web ID
– HY-120608
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C24H19ClF2N2O4S
References
– [1]Ahmad S, et al. Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. J Med Chem. 2016 Oct 13;59(19):8848-8858.
CAS Number
– 1197420-11-3
Molecular Weight
– 504.93
SMILES
– O=C1C2=C(N=CN1C3=CC=C(OCC4(O)CC(C4)(F)F)C(OC)=C3)C=C(S2)C5=CC=C(C=C5)Cl
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– MCHR1 (GPR24)
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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