Products Details

Product Description

– BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma[1].

Web ID

– HY-120629

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C25H32FN7O2

References

– [1]Santella JB 3rd, et al. From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorg Med Chem Lett. 2008;18(2):576-585.

CAS Number

– 675122-44-8

Molecular Weight

– 481.57

SMILES

– O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@H](C)[C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– CCR

Isoform

– CCR3

Pathway

– GPCR/G Protein;Immunology/Inflammation

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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