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BMS-193885
$150 – $1,250
Products Details
Product Description
– BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].
Web ID
– HY-120619
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C33H42N4O6
References
– [1]Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.|[2]Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82.
CAS Number
– 186185-03-5
Molecular Weight
– 590.71
Compound Purity
– 99.08
SMILES
– O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=C2)OC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Neuropeptide Y Receptor
Isoform
– NPY Y1 receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
