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Products Details
Product Description
– BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound containing a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It is used in synthesizing [PROTAC PD-1/PD-L1 degrader-1], which effectively inhibits the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM.
Web ID
– T40111
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H43ClN4O5
References
– Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
CAS Number
– 2447066-14-8
Molecular Weight
– C41H43ClN4O5
SMILES
– Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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