Download Files:
Products Details
Product Description
– Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].
Web ID
– HY-143873
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C55H63FN8O8S
References
– [1]Hai Xue, et al. Bcl-2 inhibitor. WO2021208963A1.
CAS Number
– 2728752-20-1
Molecular Weight
– 1015.20
SMILES
– COC(C=C1)=CC=C1CN(CC2)C[C@](C3=C(C=CC=C3)C(C)C)([H])N2C(C4)CC4(C5)CN5C6=CC(OC7=CN=C(NC=C8F)C8=C7)=C(C(NS(=O)(C9=CC([N+]([O-])=O)=C(C=C9)NC[C@@H]%10CC[C@@](O)(CC%10)C)=O)=O)C=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Isoform
– Bcl-2
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
