BAY1125976

SKU HY-100018-10 mg Category Tags , ,

$60$900

Products Details

Product Description

– BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.

Web ID

– HY-100018

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C23H21N5O

References

– [1]Politz O, et al. BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. Int J Cancer. 2017 Jan 15;140(2):449-459.

CAS Number

– 1402608-02-9

Molecular Weight

– 383.45

Compound Purity

– 99.74

SMILES

– O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– DMSO : 25 mg/mL (ultrasonic)

Target

– Akt

Isoform

– Akt1;Akt2;Akt3

Pathway

– PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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