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BAY1082439

SKU HY-100886-10 mg Category Reference compound Tags Apoptosis;PI3K, Apoptosis;PI3K/Akt/mTOR, Cancer

$90 – $750

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Products Details

Product Description

– BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].

Web ID

– HY-100886

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C25H30N6O5

References

– [1]Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.|[2]Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.

CAS Number

– 1375469-38-7

Molecular Weight

– 494.54

Compound Purity

– 98.02

SMILES

– O=C(C1=CC=CN=C1C)NC2=NC3=C(C=CC(OC[C@H](O)CN4CCOCC4)=C3OC)C5=NCCN25

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– DMSO : 5 mg/mL (ultrasonic;adjust pH to 5 with HCl)

Target

– Apoptosis;PI3K

Isoform

– PI3Kα;PI3Kβ;PI3Kδ

Pathway

– Apoptosis;PI3K/Akt/mTOR

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.