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BAY-876
$96 – $900
Products Details
Product Description
– BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth[2].
Web ID
– HY-100017
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H16F4N6O2
References
– [1]Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23.|[2]Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1).
CAS Number
– 1799753-84-6
Molecular Weight
– 496.42
Compound Purity
– 98.46
SMILES
– O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL|Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– GLUT
Isoform
– GLUT1;GLUT2;GLUT3;GLUT4
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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