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Products Details
Product Description
– BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively[1].
Web ID
– HY-150239
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H19N3O4
References
– [1]Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10(1):4925. |[2]Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.
CAS Number
– 2097610-30-3
Molecular Weight
– 401.41
SMILES
– O=C1NC2=CC(N3C(C4=CC=CC5=C4C(C3=O)=CC=C5CCCO)=O)=CC=C2N1C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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