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BACE1-IN-5
Price range: 5,232 CAD through 8,480 CAD
Products Details
Product Description
– BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-β (Aβ) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
Web ID
– T10453
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H16F5N5O2S
References
– Kusakabe KI, et al. Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central Aβ Reduction and Minimal Covalent Binding Burden. ChemMedChem. 2019 Oct 27.
CAS Number
– 2581114-83-0
Molecular Weight
– C18H16F5N5O2S
SMILES
– C[C@]1(C[C@@H](C(F)(F)F)SC(N)=N1)C2=CC(NC(=O)C=3C=NC(OCF)=CN3)=CC=C2F
Target
– Others
Pathway
– Neuroscience
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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