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B-Raf IN 1
$250 – $1,800
Products Details
Product Description
– B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
Web ID
– HY-18227
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H24F3N5O
References
– [1]Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.
CAS Number
– 950736-05-7
Molecular Weight
– 515.53
Compound Purity
– 98.66
SMILES
– O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 65 mg/mL (ultrasonic)
Target
– Raf
Isoform
– BRaf
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
