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Azido-PEG2-VHL

SKU HY-145715-Get quote Category Tags , ,

Products Details

Product Description

– Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs[1]. Azido-PEG2-VHL is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Web ID

– HY-145715

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C29H41N7O6S

References

– [1]STATSYUK A, et, al. Multikinase degraders. WO2021021797A1.|[2]Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

CAS Number

– 2597167-22-9

Molecular Weight

– 615.74

SMILES

– [N-]=[N+]=NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PROTACs

Pathway

– PROTAC

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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