Products Details

Product Description

– AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

Web ID

– HY-147744

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C24H22N4O2

References

– [1]Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg Med Chem. 2020 Jan 15;28(2):115227.

CAS Number

– 1126366-28-6

Molecular Weight

– 398.46

SMILES

– O=C(NC1=CC(C2=NC=CN2)=C(C)C=C1C)C3=CC=C(OCC4=NC=CC=C4)C=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Smo

Pathway

– Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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