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Products Details
Product Description
– AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].
Web ID
– HY-147744
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H22N4O2
References
– [1]Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg Med Chem. 2020 Jan 15;28(2):115227.
CAS Number
– 1126366-28-6
Molecular Weight
– 398.46
SMILES
– O=C(NC1=CC(C2=NC=CN2)=C(C)C=C1C)C3=CC=C(OCC4=NC=CC=C4)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Smo
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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