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AZD5582 acetate (1258392-53-8 free base)
Price range: 142 CAD through 440 CAD
Products Details
Product Description
– AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis.
Web ID
– T14378L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C60H82N8O10
Citations
– 1. Xiong Y, Luo J, Hong Z Y, et al.Hyperactivation of SREBP induces Pannexin-1-dependent lytic cell death.Journal of Lipid Research..2024
References
– Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
Molecular Weight
– C60H82N8O10
Compound Purity
– 0.9776
SMILES
– C[C@H](NC)C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2[C@H](OCC#CC#CCO[C@@H]3CC4=CC=CC=C4[C@@H]3NC([C@@H]5CCCN5C([C@@H](NC([C@@H](NC)C)=O)C6CCCCC6)=O)=O)CC7=CC=CC=C27)=O)=O)C8CCCCC8)=O.CC(O)=O
Target
– Others
Pathway
– Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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