AZD-1480
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AZD-1480

SKU T3069-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 83 CAD through 229 CAD

Products Details

Product Description

– AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.

Web ID

– T3069

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H14ClFN8

Citations

– 1. Yang T, Shi X, Kang Y, et al. Novel compounds TAD-1822-7-F2 and F5 inhibited HeLa cells growth through the JAK/Stat signaling pathway. Biochemical & Pharmacology. 2018, 103: 118-126 2. Hu Z, Sui Q, Jin X, et al.IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma.Journal of Experimental & Clinical Cancer Research.2024, 43(1): 63.

References

– E Derenzini, et al. Blood Cancer J, 2011, 1(12), e46.

CAS Number

– 935666-88-9

Molecular Weight

– C14H14ClFN8

Compound Purity

– 0.9825

SMILES

– C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1

Pathway

– Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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