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AZ505 (ditrifluoroacetate)
$170 – $900
Products Details
Product Description
– AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM.
Web ID
– HY-15226A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H40Cl2F6N4O8
Citations
– Development. 2020 Sep 28;147(18):dev190678. |Exp Cell Res. 2021 May 17;112649.|Mol Carcinog. 2023 Apr 10.|Am J Physiol Renal Physiol. 2022 Jun 27.|Cell Death Dis. 2018 Feb 27;9(3):326.|Cell Death Dis. 2021 May 2;12(5):439.|Cell Death Dis. 2022 Jan 12;13(1):52.|Cell Death Discov. 2022 Jun 6;8(1):274.|Cells. 2022 Apr 8;11(8):1262.|Chem Rev. 2021;28(4):297-305.|FASEB J. 2021 Jul;35(7):e21715.|J Clin Invest. 2017 Jun 30;127(7):2751-2764.|Mol Carcinog. 2023 May 5.|Oncogene. 2021 Apr;40(15):2711-2724.|Research Square Preprint. 2021 Oct.|Research Square Print. 2023 Mar 21.|Sci Adv. 2020 Oct 30;6(44):eabb3154.|Sci Adv. 2023 Jun 16;9(24):eade6624.|Theranostics. 2019 Oct 22;9(26):8377-8391.Â
References
– [1]Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.|[2]Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20;112(2):357-64.
CAS Number
– 1035227-44-1
Molecular Weight
– 805.59
Compound Purity
– 99.91
SMILES
– O=C(N(C1CCCCC1)CCNCCC2=C(OCC(N3)=O)C3=C(O)C=C2)CCNCCC4=CC=C(Cl)C(Cl)=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 125 mg/mL
Target
– Histone Methyltransferase
Isoform
– SMYD2
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
