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Avibactam (free acid)
$72 – $228
Products Details
Product Description
– Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
Web ID
– HY-14879
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C7H11N3O6S
Citations
– Antibiotics (Basel). 2023 Jul 20, 12(7), 1212.|Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02260-16.|Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01809-18.|Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01374-19.|Antimicrob Agents Chemother. 2019 Sep 16;63(12):e01515-19.|Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02025-19.|Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00409-20.|Antimicrob Agents Chemother. 2023 May 18;e0160322.|Antimicrob Agents Chemother. 2023 May 31;e0033923.|Antimicrob Agents Chemother. 2023 Sep 6;e0052823.|Antimicrob Agents Chemother. 2023 Sep 8;e0030123.|Biomed Res Int. 2018 Jul 2;2018:3579832. |BMC Microbiol. 2020 Jun 29;20(1):187.|BMC Microbiol. 2019 Nov 1;19(1):240.|Int J Med Microbiol. 2020 Jul;69(7):928-931.|J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.|J Antimicrob Chemother. 2017 Sep 1;72(9):2483-2488.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|J Clin Microbiol. 2023 Apr 18;e0164722.|Microb Drug Resist. 2020 Apr;26(4):334-340.|Microbiol Spectr. 2023 Apr 24;e0069223.|Preprints. 2023 Jun 21.|ACS Infect Dis. 2021 Jun 30.|Acta Microbiol Immunol Hung. 2021 Jul 29.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Antibiotics (Basel). 2021, 10(11), 1341.|Antibiotics (Basel). 2022, 11(10), 1280.|Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00414-18. |Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00433-18.|Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00282-18. |Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00873-18.|Antimicrob Agents Chemother. 2022 Jun 1;e0240221.|Antimicrob Agents Chemother. 2023 Jan 23;e0145922.|bioRxiv. 2021 Mar 13.|Biosens Bioelectron. 2021 Jul 21;193:113526.|Infect Drug Resist. 2020 Aug 18;13:2883-2890.|Infect Drug Resist. 2021 Jun 30;14:2499-2507.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Int J Infect Dis. 2020 Apr;93:252-257. |Int J Med Microbiol. 2021 Oct;70(10).|Int J Mol Sci. 2021, 22(6), 3051.|J Antimicrob Chemother. 2021 Feb 11;76(3):653-658.|J Antimicrob Chemother. 2021 May 6;dkab141.|J Antimicrob Chemother. 2022 Jul 15;dkac232.|J Antimicrob Chemother. 2023 Feb 13;dkad032.|J Infect Dev Ctries. 2021 Mar 31;15(3):404-414.|J Infect Dis. 2019 Jul 2;220(3):484-493. |Microbiol Spectr. 2022 Aug 16;e0139022.|Microbiol Spectr. 2022 Aug 24;e0203522.|Microbiol Spectr. 2022 Dec 8;e0303822.|Microbiol Spectr. 2023 Nov 20:e0304723.|RSC Adv. 2023 Nov 30;13(49):34884-34890.|Sci Rep. 2022 Oct 7;12(1):16814.|Int J Infect Dis. 2021 Apr 14;S1201-9712(21)00346-5.|J Clin Microbiol. 2020 Aug 24;58(9):e00932-20.
References
– [1]Berkhout J, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.|[2]Ehmann DE, et al.
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.|[3]Livermore DM, et al.
Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104).
J Antimicrob Chemother. 2012 Jun;67(6):1354-8.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.
CAS Number
– 1192500-31-4
Molecular Weight
– 265.24
Compound Purity
– 99.22
SMILES
– O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O)=O
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Antibiotic;Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
