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AVE 0991 (sodium salt)
$300 – $1,680
Products Details
Product Description
– AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM[1].
Web ID
– HY-15778A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H31N4NaO5S2
Citations
– Blood. 2015 Jan 22;125(4):710-9.|Aging (Albany NY). 2018 Apr 17;10(4):645-657. |Diabetes. 2017 Aug;66(8):2201-2212. |Exp Anim. 2022 Aug 8.|Front Aging Neurosci. 2021 Feb 15.|J Hepatol. 2022 Nov 9;S0168-8278(22)03285-8.|J Inflamm Res. 2021 Dec 18;14:7007-7019.|PLoS One. 2015 Nov 5;10(11):e0142087.|Redox Biol. 2019 Jan;20:75-86.|Research Square Preprint. 2021 Nov.
References
– [1]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6.|[2]Ferreira AJ, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1113-9.|[3]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002 Dec;40(6):847-52.
CAS Number
– 306288-04-0
Molecular Weight
– 602.70
Compound Purity
– 98.75
SMILES
– O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)([N-]C(NCC)=O)=O.[Na+]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease; Endocrinology
Solubility
– DMSO : ≥ 55 mg/mL|H2O : 50 mg/mL (ultrasonic)
Target
– Angiotensin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
