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Products Details
Product Description
– Aurora Kinases-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10[1].
Web ID
– HY-151971
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H16F3N3O4
References
– [1]Lv G, et al. 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904.
CAS Number
– 2840558-83-8
Molecular Weight
– 419.35
SMILES
– CNC(C1=CC(OC(F)(F)F)=CC(OC2=C(C=CC=N2)C3=CC(OC)=NC=C3)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase;Polo-like Kinase (PLK)
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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