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Products Details
Product Description
– Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC50s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity[1].
Web ID
– HY-147703
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H17Cl2N3O4S
References
– [1]Al-Sanea MM, et al. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorg Med Chem. 2020 Jul 1;28(13):115525.
CAS Number
– 2419107-09-6
Molecular Weight
– 454.33
SMILES
– CCOC(C1=C(C2=C(C=C(C=C2N=C1)Cl)Cl)NC3=CC(S(=O)(NC)=O)=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase
Isoform
– Aurora A;Aurora B
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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