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Products Details
Product Description
– Aurora kinase inhibitor-10 (Compound 6c) is an orally active Aurora B inhibitor with an IC50 of 8 nM. Aurora kinase inhibitor-10 shows antitumor activity[1].
Web ID
– HY-147993
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H19F5N6O4S
References
– [1]Tamizharasan N, et al. Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors. Bioorg Chem. 2020 Jun;99:103800.
CAS Number
– 2417228-90-9
Molecular Weight
– 546.47
SMILES
– O=S(C1=CC=C(NC2=NC=C(F)C(N3CCNC4=CC(F)=CC=C4C3)=N2)C=C1)(N)=O.O=C(C(F)(F)F)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase
Isoform
– Aurora B
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
