Download Files:
Atorvastatin
$55 – $132
Products Details
Product Description
– Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
Web ID
– HY-B0589
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C33H35FN2O5
Citations
– Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658.|Biomed Pharmacother. 2023 Aug 12;166:115323.|Biotechnol Bioeng. 2021 Sep 3.|Cancer Lett. 2022 Oct 19;215976.|Cell Cycle. 2019 Dec;18(23):3337-3350.|Cell Cycle. 2021 Sep 8;1-14.|Endocrinology. 2022 May 18;bqac076.|Eur J Pharmacol. 2023 Aug 1;956:175938.|Exp Cell Res. 2023 Oct 23:113829.|Front Cell Dev Biol. 2022 Mar 3;10:806081.|Int J Mol Sci. 2023 Apr 19, 24(8), 7492.|J Mol Neurosci. 2021 Sep 26.|J Nat Prod. 2022 Jun 24.|J Neuroimmunol. 2020 Oct 24;350:577429.|Mol Cell. 2021 Jul 1;81(13):2736-2751.e8.|Naunyn Schmiedebergs Arch Pharmacol. 2023 Jun 8.|Oncogene. 2022 Oct 31.|Phytomedicine. 2023 Jul 26;119:154997.|Proteomics. 2023 May 4;e2300041.|Research Square Preprint. 2021 Dec.|Research Square Preprint. 2022 Jun.|Sci Rep. 2020 Jan 28;10(1):1308.|Cell Death Dis. 2021 May 13;12(5):482.|Endocrinology. 2018 May 1;159(5):2008-2021.|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Pharmaceutics. 2022, 14(1), 176.
References
– [1]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.|[2]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.|[3]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.|[4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.|[5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.|[6]Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.
CAS Number
– 134523-00-5
Molecular Weight
– 558.64
Compound Purity
– 99.64
SMILES
– O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[C@@H](O)C[C@@H](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4
Clinical Information
– Launched
Research Area
– Metabolic Disease; Inflammation/Immunology; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Autophagy;HMG-CoA Reductase (HMGCR)
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
