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Products Details
Product Description
– ATM Inhibitor-8 (Compound 10r) is a highly potent, selective and orally active ATM inhibitor,with an IC50 of 1.15 nM. ATM Inhibitor-8 exhibits anti-tumor activity[1].
Web ID
– HY-155090
Shipping
– Room temperature
Molecular Formula
– C26H34N6O2
References
– [1]D Deng, et al. Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. J Med Chem. 2023 Jul 27，
Molecular Weight
– 462.59
SMILES
– CN(C1=NC2=CC(C3=CN=C(C=C3)OCCCN4CCCCC4)=CC=C2N=C1)C(NC(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
