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AT9283
Price range: 62 CAD through 1,544 CAD
Products Details
Product Description
– AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Web ID
– T3068
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H23N7O2
Citations
– 1. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866.
2. Hou W, Wang Z Y, Lin J, et al. Induction of differentiation of the acute myeloid leukemia cell line (HL-60) by a securinine dimer. Cell Death Discovery. 2020, 6(1): 1-11
References
– Howard S, et al. J Med Chem, 2009, 52(2), 379-388.
CAS Number
– 896466-04-9
Molecular Weight
– C19H23N7O2
Compound Purity
– 0.9987
SMILES
– O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1
Pathway
– Apoptosis|||Cytoskeletal Signaling|||Cell Cycle/Checkpoint|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Autophagy|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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