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AT7519
Price range: 83 CAD through 360 CAD
Products Details
Product Description
– AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.
Web ID
– T6205
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H17Cl2N5O2
Citations
– 1. Kazi A, Chen L, Xiang S, et al. Global Phosphoproteomics reveal CDK suppression as a vulnerability to KRAS addiction in Pancreatic Cancer. Clinical Cancer Research. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20.
2. Zhao W, Zhang L, Zhang Y, et al.The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.Cell Death & Disease.2023, 14(1): 11.
3. Long Y, Jia X, Chu L.Insight into the structure, function and the tumor suppression effect of gasdermin E.Biochemical Pharmacology.2024: 116348.
References
– Squires MS, et al. Mol Cancer Ther, 2009, 8(2), 324-332.
CAS Number
– 844442-38-2
Molecular Weight
– C16H17Cl2N5O2
Compound Purity
– 0.9967
SMILES
– N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3CCNCC3)=O)=NNC2
Pathway
– Cell Cycle/Checkpoint|||Apoptosis|||PI3K/Akt/mTOR signaling|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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