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Astragaloside IV
Price range: 51 CAD through 856 CAD
Products Details
Product Description
– Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
Web ID
– T2973
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H68O14
Citations
– 1. Chen X, Tian C, Zhang Z, et al.Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction.Frontiers in Bioscience-Landmark.2023, 28(3): 45.
2. Zhang X, Yan W, Chen X, et al.Long-term 4-nonylphenol Exposure Drives Cervical Cell Malignancy Through MAPK-mediated Ferroptosis Inhibition.Journal of Hazardous Materials.2024: 134371.
References
– Li M, et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)3201994-6
CAS Number
– 84687-43-4
Molecular Weight
– C41H68O14
Compound Purity
– 0.9984
SMILES
– CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@H](O)C[C@@]2(C)C3C[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C4[C@]5(CC35CC[C@]12C)CCC(O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)C4(C)C
Pathway
– Endocrinology/Hormones|||Proteases/Proteasome|||MAPK
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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