Astragaloside IV
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Astragaloside IV

SKU T2973-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 856 CAD

Products Details

Product Description

– Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

Web ID

– T2973

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C41H68O14

Citations

– 1. Chen X, Tian C, Zhang Z, et al.Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction.Frontiers in Bioscience-Landmark.2023, 28(3): 45. 2. Zhang X, Yan W, Chen X, et al.Long-term 4-nonylphenol Exposure Drives Cervical Cell Malignancy Through MAPK-mediated Ferroptosis Inhibition.Journal of Hazardous Materials.2024: 134371.

References

– Li M, et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)3201994-6

CAS Number

– 84687-43-4

Molecular Weight

– C41H68O14

Compound Purity

– 0.9984

SMILES

– CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@H](O)C[C@@]2(C)C3C[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C4[C@]5(CC35CC[C@]12C)CCC(O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)C4(C)C

Pathway

– Endocrinology/Hormones|||Proteases/Proteasome|||MAPK

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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