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Astaxanthin
$55 – $77
Products Details
Product Description
– Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].
Web ID
– HY-B2163
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C40H52O4
References
– [1]Sun SQ, et al. Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer. Mar Drugs. 2020 Aug 7;18(8):415. |[2]Fu D, et al. Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study. Biomed Res, 2017, 28(15): 6839-6843. |[3]Zhang X, et al. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys. 2011 Aug 1;512(1):96-106. |[4]Gross GJ, et al. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol Cell Biochem. 2006 Feb;283(1-2):23-30. |[5]Zhang L, et al. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs. 2015 Jul 14;13(7):4310-30.
CAS Number
– 472-61-7
Molecular Weight
– 596.84
Compound Purity
– 98.0
SMILES
– CC(/C=C/C(C(C)(C[C@H](O)C1=O)C)=C1C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC(C(C)(C[C@H](O)C2=O)C)=C2C
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease; Cardiovascular Disease
Solubility
– DMSO : 2 mg/mL (ultrasonic)
Target
– Apoptosis;NF-κB;PPAR;Reactive Oxygen Species;STAT
Isoform
– PPARγ;STAT3
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;JAK/STAT Signaling;Metabolic Enzyme/Protease;NF-κB;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
