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AST 487
Price range: 50 CAD through 1,952 CAD
Products Details
Product Description
– AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
Web ID
– T4053
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H30F3N7O2
Citations
– 1. Agarwal N, Zhou Q, Arya D, et al. AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10819.
References
– Akeno-Stuart N, et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells. Cancer Res. 2007 Jul 15;67(14):6956-64.
CAS Number
– 630124-46-8
Molecular Weight
– C26H30F3N7O2
Compound Purity
– 0.9817
SMILES
– C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4
Pathway
– Cytoskeletal Signaling|||Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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