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Products Details
Product Description
– ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].
Web ID
– HY-146729
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H18N8O2
References
– [1]Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277.
CAS Number
– 2426705-19-1
Molecular Weight
– 378.39
SMILES
– C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MAP3K
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
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