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AS1269574
SKU
HY-107535-10 mg
Category Reference compound
Tags GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling, GPR119;TRP Channel, Metabolic Disease
$83 – $660
Products Details
Product Description
– AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].
Web ID
– HY-107535
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C13H14BrN3O
References
– [1]Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441.|[2]Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629.
CAS Number
– 330981-72-1
Molecular Weight
– 308.17
Compound Purity
– 98.76
SMILES
– OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– GPR119;TRP Channel
Isoform
– TRPA
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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