APY29
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APY29

SKU T3654-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 1,904 CAD

Products Details

Product Description

– APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

Web ID

– T3654

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H16N8

Citations

– 1. Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962.

References

– Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al. (2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology, 8(12), 982-989. doi: 10.1038/nchembio.1094

CAS Number

– 1216665-49-4

Molecular Weight

– C17H16N8

Compound Purity

– 0.9846

SMILES

– C1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1

Pathway

– Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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