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Product Description
– Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki=0.08 μM), as well as inhibits DNA polymerases α, β, and γ with Ki value of 300 μM, 12 μM, and 112.25 μM, respectively[1]. Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection[2].
Web ID
– HY-14913
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C8H11N3O3S
References
– [1]de Muys JM, et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine.Antimicrob Agents Chemother. 1999 Aug;43(8):1835-44.|[2]Cahn P, et al. Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients.AIDS. 2006 Jun 12;20(9):1261-8.
CAS Number
– 160707-69-7
Molecular Weight
– 229.26
SMILES
– O=C1N=C(N)C=CN1[C@@H]2S[C@H](CO)OC2
Clinical Information
– Phase 3
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis;HIV;Nucleoside Antimetabolite/Analog
Isoform
– HIV-1
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
