Apricitabine
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Apricitabine

SKU T14313-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 502 CAD through 4,768 CAD

Products Details

Product Description

– Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

Web ID

– T14313

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C8H11N3O3S

References

– de Muys JM, et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine.Antimicrob Agents Chemother. 1999 ; 43(8):1835-1844.

CAS Number

– 160707-69-7

Molecular Weight

– C8H11N3O3S

Compound Purity

– 1

SMILES

– O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Proteases/Proteasome|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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